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The Science Behind MemorAmp

Our technology is built on years of research into Alzheimer’s and dementia biomarkers. By combining graphene biosensors with advanced biochemistry, MemorAmp detects Alzheimer's linked biomarkers earlier than traditional methods.

What We Measure

Alzheimer’s and related dementias leave early molecular “footprints” in the body. These biomarkers are proteins that can be detected long before symptoms appear.

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Medical Consultation

Amyloid-beta (Aβ42): linked to plaque formation.

Tau: indicates brain cell damage.

Alpha-synuclein: tied to Parkinson’s and dementia.

TDP-43: associated with frontotemporal dementia.

Detecting Disease Before It Shows

Traditional Alzheimer’s diagnosis relies on memory tests or brain scans, often after the disease has progressed. Biomarker detection allows us to intervene years earlier, giving patients and families the gift of time.

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Ultra-Sensitive Graphene Biosensors

Graphene, one of the strongest and most conductive materials on Earth, allows us to detect biomarkers at ultra-low concentrations. Paired with DNA aptamers (molecules that “lock” onto specific proteins), our biosensors offer unmatched accuracy and speed.

UCSD Validation

MemorAmp’s technology is discovered and designed as a result of research conducted at UC San Diego, under the direction of Professor Ratnesh Lal.  The continuation patents (Patent No. 12411135, September 2025) cover biosensor methods and devices using graphene FET chips.

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Memoramp: From Concept to Creation

Memoramp began as a scientific exploration into how humans retain and connect knowledge. Born in the Science Lab, it evolved into a platform that transforms research into collective memory.

Publications

MemorAmp Papers and Patents (2016–2025)

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Single-Molecule DNA Detection with GFET

Between 2016 and 2022, MemorAmp advanced graphene field-effect transistor (GFET) sensors for single-molecule DNA and RNA detection. Using aptamer-based probes, this portable system enabled label-free, real-time analysis — a breakthrough for personalized diagnostics and pandemic response.

Includes PNAS (2016) and COVID-19 detection patents (2017).

Biomarker Detection for Alzheimer’s Disease

Using aptamer-modified GFETs, MemorAmp detected Alzheimer’s biomarkers from human brain tissue. Published in PNAS (2023) with a 2024 patent for dementia diagnostics, this innovation paved the way for noninvasive early detection of neurodegenerative diseases.

Therapeutic Strategies to Reverse Alzheimer’s Pathology

Building on amyloid ion channel research, MemorAmp developed small-molecule drugs and nanobowl-based amyloid removal methods to reduce toxicity pathways. Featured in EMBO Molecular Medicine (2018) and Biophysical Journal (2021).

2006–2015

Comprehensive studies of protein misfolding and amyloid ion channel structures, shaping Alzheimer’s research.

1998–2005

Breakthrough discoveries on amyloid ion channels and their role in neurodegenerative disease.

1991–1997

Foundational work in atomic force microscopy and gap junction characterization, leading to insights into protein misfolding.

P.O. Box 2613, Palm Beach, Florida

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